Hormone Therapy for Breast Cancer

Pregnenolone can either be converted to 17-hydroxypregnolone and consequently to dehydroepiandrosterone by 17α-hydroxylase (CYP17), or it can be converted to progesterone by 3β-hydroxysteroid dehydrogenase (3β-HSD) 33. Both dehydroepiandrosterone and progesterone are then converted to androstenedione by 3β-HSD and CYP17, respectively 33. Afterwards, the androstenedione can be either converted to testosterone by 17β-hydroxysteroid dehydrogenase (17β-HSD), or to E1 by the aromatase enzyme (CYP19A1) 33. Finally, if you want to keep your estrogen levels healthy relative to your testosterone, avoid testosterone therapy like the plague. Too much estrogen binding in breast tissue is one of the leading causes of breast cancer, so finding ways to decrease estrogen production has been a serious aim of front-line research for a few decades. Your doctor may recommend that you stop taking Arimidex “cold turkey,” meaning all at once.

Who can take aromatase inhibitors?

These medications also are prescribed for premenopausal women in combination with ovarian suppression therapy and for men with breast cancer who are unable to take tamoxifen. During the mid to late 1990s there was a trend for many women to turn to “natural” alternative therapies to treat perimenopausal and postmenopausal symptoms 76. Also during this interval recall, in 1991 the women’s health initiative (WHI) started and was to run until 2005 but was stopped after an average follow-up of 5.2 years. The WHI investigators’ report was published in July of 2002 in the Journal of the American Medical Association (JAMA), which generated confusion due to the fact that the general public did not know how to understand the data 78. This report provided a strong initiative for women to investigate in a more dramatic fashion the use of alternative therapies 76, 79. Concurrently, Adlercreutz reported in the early 2000s that phytoestrogens had a preventive effect against various cancers and breast cancer specifically.

• The impact of AIs on the renal system has not been sufficiently studied.
• Research letters, prospective case series, and conference abstracts reporting prospective findings were included if they specified, at minimum, inclusion criteria, intervention(s), outcome(s), and follow-up duration.
• Before starting therapy with AIs, always discuss your health history and any medications you’re taking with your doctor so they can help you minimize risks and side effects.

Hormone Therapy for Breast Cancer

Anastrazole treatment also produced similar results in female rats 185. In light of these findings, further investigation is needed to determine if renal toxicity is a potential adverse effect of AIs. CKD is recognized as a common clinical problem with elderly patients. Recent estimates by the Center of Disease Control and Prevention showed that CKD is more prevalent in individuals over the age of 65 (38%) compared to those between the ages of 45–64 (12%) and 18–44 (6%) 19.

Aromasin and breastfeeding

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In investigating other biochemicals, the compound extracted from the tree Ginkgo biloba displayed aromatase inhibitory effects at both the enzyme (JEG-3 cells) and CYP19A1 expression levels 102. This study also examined specific promoter CYP19A1 sequences in recombinant microsomes, which suggested a dose-dependent decline in aromatase gene expression that may have potential applications to breast cancer 102. Conversely, Ye et al. reported that the isoflavone, genistein, induced aromatase activity and increased aromatase mRNA expression in hepatic cells (HepG2) with the concurrent utilization of the CYP19A1 promoters 1.3 and II 104.

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