Hormone Therapy for Breast Cancer
Hormone Therapy for Breast Cancer Pregnenolone can either be converted to 17-hydroxypregnolone and consequently to dehydroepiandrosterone by 17α-hydroxylase (CYP17), or it can be converted to progesterone by 3β-hydroxysteroid dehydrogenase (3β-HSD) 33. Both dehydroepiandrosterone and progesterone are then converted to androstenedione…